Ephraim was hooked. Education, fine minds, the good of all — this work had to be done. He offered to join the campaign to start the University of Dakota, for his Baptist circuits provided an ideal opportunity to build support. Mr Kettering gladly welcomed the respected, highly-educated Dr Epstein. The founding trustees were tough, intelligent men and Ephraim savoured working with them as equals conferring over petitions, deadlines and charter requirements. With a cause to fight for Ephraim became fully his old self. His dispirited determination ceased, his withdrawals to his desk were now charged with energy. Helena rejoiced in his zeal; at last her husband was the confident, enthusiastic man she had fallen in love with.
Finally, two years after the awful death of his little son, Ephraim regains purpose in life, though he still feels unable to practice medicine. In Chapter 31, Orion Rising, his engagement in the new cause of a university for the raw Dakota Territory is interrupted by the devastating Great Flood of 1881. By mid-April 400 miles of the Missouri River had been inundated and the worst destruction is in the 25 miles between Yankton, where Ephraim lives, and Vermillion — the town designated as home to the university. The whole settlement of Vermillion has been washed away. Lesser men would be fazed, but Ephraim?